Novel GABA receptor pesticide targets
نویسندگان
چکیده
منابع مشابه
GABAA Receptor Subtypes: Novel Targets for Novel Medicines
Copyright © 2012 Naheed R. Mirza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. GABA A receptors are ligand gated ion channels that are targeted by drugs with multiple therapeutic applications. Most notably, such drugs inc...
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Our understanding of the role GABA(C) receptors play in the central nervous system is limited due to a lack of specific ligands. Here we describe the pharmacological effects of (+/-)-cis-3- and (+/-)-trans-3-(aminocyclopentyl)methylphosphinic acids ((+/-)-cis- and (+/-)-trans-3-ACPMPA) as novel ligands for the GABA(C) receptor showing little activity at GABA(A) or GABA(B) receptors. (+/-)-cis-3...
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The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (gamma-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABA(A) and GABA(C) receptors, and specific interactions between GABA and some of these residues have been determined. In the present paper, I show how...
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GABA(C) receptors are the least studied of the three major classes of GABA receptors. The physiological roles of GABA(C) receptors are still being unravelled and the pharmacology of these receptors is being developed. A range of agents has been described that act on GABA(C) receptors with varying degrees of specificity as agonists, partial agonists, antagonists and allosteric modulators. Pharma...
متن کاملAn exciting GABA receptor
NATURE REVIEWS | NEUROSCIENCE VOLUME 4 | DECEMBER2003 | 937 GABA (γ-aminobutyric acid) is a classical inhibitory neurotransmitter, although it has been suggested that it might mediate excitation in some adult neurons. Beg and Jorgensen, writing in Nature Neuroscience, have characterized an unusual GABA receptor that is selective for cations rather than anions, giving it an excitatory effect. Th...
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ژورنال
عنوان ژورنال: Pesticide Biochemistry and Physiology
سال: 2015
ISSN: 0048-3575
DOI: 10.1016/j.pestbp.2014.11.006